Etorphine induces pathophysiology in immobilized white rhinoceros through sympathomimesis that is attenuated by butorphanol

dc.contributor.authorBoesch, Jordyn M.
dc.contributor.authorGleed, Robin D.
dc.contributor.authorBuss, Peter Erik
dc.contributor.authorTordiffe, Adrian Stephen Wolferstan
dc.contributor.authorZeiler, Gareth Edward
dc.contributor.authorMiller, Michele A.
dc.contributor.authorViljoen, Francois
dc.contributor.authorHarvey, Brian H.
dc.contributor.authorParry, Stephen A.
dc.contributor.authorMeyer, Leith Carl Rodney
dc.date.accessioned2025-10-30T09:28:12Z
dc.date.available2025-10-30T09:28:12Z
dc.date.issued2025-04
dc.descriptionDATA AVAILABILITY : All relevant data and resources can be found within the article and its supplementary information.
dc.description.abstractPlease read abstract in the article. LAY SUMMARY White rhinoceros are a sentinel species for ecosystems in southern Africa. Their conservation is dependent on occasional immobilization with the ultra-potent opioid etorphine. Unfortunately, etorphine produces sympathetic nervous system upregulation and severe physiological perturbations that may cause morbidity and mortality. Attenuating its effects contributes to white rhinoceros conservation.
dc.description.departmentParaclinical Sciences
dc.description.departmentCompanion Animal Clinical Studies
dc.description.librarianhj2025
dc.description.sdgSDG-03: Good health and well-being
dc.description.sdgSDG-15: Life on land
dc.description.sponsorshipThis work was supported by the John T. and Jane A. Wiederhold Foundation, Cornell University; the Department of Paraclinical Sciences, University of Pretoria (UP); South African National Parks (SANParks); the South African Veterinary Association Wildife Group; the South African National Research Foundation; and Wildlife Pharmaceuticals South Africa.
dc.description.urihttps://academic.oup.com/conphys
dc.identifier.citationJordyn M. Boesch, Robin D. Gleed, Peter E. Buss, Adrian S.W. Tordiffe, Gareth E. Zeiler, Michele A. Miller, Francois Viljoen, Brian H. Harvey, Stephen A. Parry, Leith C.R. Meyer, Etorphine induces pathophysiology in immobilized white rhinoceros through sympathomimesis that is attenuated by butorphanol, Conservation Physiology, Volume 13, Issue 1, 2025, coaf009, pp. 1-21, https://doi.org/10.1093/conphys/coaf009.
dc.identifier.issn2051-1434 (online)
dc.identifier.other10.1093/conphys/coaf009
dc.identifier.urihttp://hdl.handle.net/2263/105048
dc.language.isoen
dc.publisherOxford University Press
dc.rights© The Author(s) 2025. Published by Oxford University Press and the Society for Experimental Biology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
dc.subjectButorphanol
dc.subjectCeratotherium simum
dc.subjectWhite rhinoceros (Ceratotherium simum)
dc.subjectEtorphine
dc.subjectHypoxaemia
dc.subjectNoradrenaline
dc.subjectSympathetic
dc.subjectConservation
dc.titleEtorphine induces pathophysiology in immobilized white rhinoceros through sympathomimesis that is attenuated by butorphanol
dc.typeArticle

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